Katherine Heigl & Josh Kelley – Izzie Stevens
Katherine Heigl is an incredibly talented actress who has been the leading lady in many roles such as 27 Dresses and The Ugly Truth. She played Izzie Stevens in Grey’s Anatomy and was a huge hit with fans throughout her five years with the show. She married Josh Kelley in 2007, although they were dating for a year prior to that. They’ve adopted two children and then she became pregnant and gave birth to the third child. Their first kid, Naleigh, suffered heart problems and prior to being adopted had required surgery.